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Initial DNA interactions of the binuclear threading intercalator Λ,Λ-[μ-bidppz(bipy)4Ru2]4+: an NMR study with [d(CGCGAATTCGCG)]2.

Abstract:

Binuclear polypyridine ruthenium compounds have been shown to slowly intercalate into DNA, following a fast initial binding on the DNA surface. For these compounds, intercalation requires threading of a bulky substituent, containing one Ru(II), through the DNA base-pair stack, and the accompanying DNA duplex distortions are much more severe than with intercalation of mononuclear compounds. Structural understanding of the process of intercalation may greatly gain from a characterisation of the...

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Publication status:
Published

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Publisher copy:
10.1002/chem.201203175

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemistry (Weinheim an der Bergstrasse, Germany) More from this journal
Volume:
19
Issue:
17
Pages:
5401-5410
Publication date:
2013-04-01
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Language:
English
Keywords:
Pubs id:
pubs:400105
UUID:
uuid:ace38c08-73cf-4cbb-9a12-f894bae2ac95
Local pid:
pubs:400105
Source identifiers:
400105
Deposit date:
2013-11-16

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