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TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis

Abstract:

The TRAIL pathway can mediate apoptosis of hepatic stellate cells to promote the resolution of liver fibrosis. However, TRAIL has the capacity to bind to regulatory receptors in addition to death-inducing receptors; their differential roles in liver fibrosis have not been investigated. Here we have dissected the contribution of regulatory TRAIL receptors to apoptosis resistance in primary human hepatic stellate cells (hHSC). hHSC isolated from healthy margins of liver resections from differen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-05845-5

Authors


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ORCID:
0000-0002-1433-1711
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ORCID:
0000-0001-9440-0571
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
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Funding agency for:
Otano, I
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Funding agency for:
Maini, MK
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific reports Journal website
Volume:
7
Issue:
2017
Pages:
1-11
Publication date:
2017-07-17
Acceptance date:
2017-06-12
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:816573
URN:
uri:ace2be11-08c1-4fb0-8537-f9ce7bda49f9
UUID:
uuid:ace2be11-08c1-4fb0-8537-f9ce7bda49f9
Local pid:
pubs:816573
Language:
English
Keywords:

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