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Amplification of DNA damage by a γH2AX-targeted radiopharmaceutical.

Abstract:

(111)In-DTPA-anti-γH2AX-Tat, which combines an anti-γH2AX antibody with a cell-penetrating peptide, Tat, and the Auger electron-emitting radioisotope, (111)In, targets the DNA damage signalling protein, γH2AX, and has potential as a probe for imaging DNA damage in vivo. The goal of this study was to investigate whether (111)In-DTPA-anti-γH2AX-Tat labelled to high specific activity (6MBq/μg) can amplify treatment-related DNA damage for therapeutic gain.MDA-MB-468 and MDA-MB-231/H2N (231-H2N) b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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CR-UK/EPSRC/MRC/ NIHR Oxford Cancer Imaging Centre More from this funder
Oxford Experimental Cancer Medicine Centre More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Cancer Research UK More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Nuclear medicine and biology Journal website
Volume:
39
Issue:
8
Pages:
1142-1151
Publication date:
2012-11-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:acc4029a-902c-4dc5-8add-9f3f1ec59ffa
Source identifiers:
344341
Local pid:
pubs:344341

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