- Abstract:
-
(111)In-DTPA-anti-γH2AX-Tat, which combines an anti-γH2AX antibody with a cell-penetrating peptide, Tat, and the Auger electron-emitting radioisotope, (111)In, targets the DNA damage signalling protein, γH2AX, and has potential as a probe for imaging DNA damage in vivo. The goal of this study was to investigate whether (111)In-DTPA-anti-γH2AX-Tat labelled to high specific activity (6MBq/μg) can amplify treatment-related DNA damage for therapeutic gain.MDA-MB-468 and MDA-MB-231/H2N (231-H2N) b...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.nucmedbio.2012.06.001
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Nuclear medicine and biology Journal website
- Volume:
- 39
- Issue:
- 8
- Pages:
- 1142-1151
- Publication date:
- 2012-11-05
- DOI:
- EISSN:
-
1872-9614
- ISSN:
-
0969-8051
- URN:
-
uuid:acc4029a-902c-4dc5-8add-9f3f1ec59ffa
- Source identifiers:
-
344341
- Local pid:
- pubs:344341
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2012
Journal article
Amplification of DNA damage by a γH2AX-targeted radiopharmaceutical.
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CR-UK/EPSRC/MRC/
NIHR Oxford Cancer Imaging Centre
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Oxford Experimental Cancer Medicine Centre
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National Institute for Health Research Oxford Biomedical Research Centre
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Cancer
Research UK
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