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Journal article

Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study.

Abstract:

Patients with muscular dystrophy have abnormal cardiac function and decreased high-energy phosphate metabolism. Here, we have determined whether the 8 month old mdx mouse, an animal model of muscular dystrophy, also has abnormal cardiac function and energetics. In vivo cardiac MRI revealed 33% and 104% larger right ventricular end-diastolic and end-systolic volumes, respectively, and 17% lower right ventricular ejection fractions in mdx mice compared with controls. Evidence of left ventricula...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2008.09.125

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
Journal of molecular and cellular cardiology
Volume:
45
Issue:
6
Pages:
754-760
Publication date:
2008-12-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:acbff1ce-ef8d-4ebe-bd5e-d075d108e8c5
Source identifiers:
104950
Local pid:
pubs:104950

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