- Abstract:
-
Patients with muscular dystrophy have abnormal cardiac function and decreased high-energy phosphate metabolism. Here, we have determined whether the 8 month old mdx mouse, an animal model of muscular dystrophy, also has abnormal cardiac function and energetics. In vivo cardiac MRI revealed 33% and 104% larger right ventricular end-diastolic and end-systolic volumes, respectively, and 17% lower right ventricular ejection fractions in mdx mice compared with controls. Evidence of left ventricula...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.yjmcc.2008.09.125
-
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- Journal:
- Journal of molecular and cellular cardiology
- Volume:
- 45
- Issue:
- 6
- Pages:
- 754-760
- Publication date:
- 2008-12-05
- DOI:
- EISSN:
-
1095-8584
- ISSN:
-
0022-2828
- URN:
-
uuid:acbff1ce-ef8d-4ebe-bd5e-d075d108e8c5
- Source identifiers:
-
104950
- Local pid:
- pubs:104950
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study.
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