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Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.

Abstract:

We previously demonstrated that proto-oncogene Fyn decreased energy expenditure and increased metabolic phenotypes. Also Fyn decreased autophagy-mediated muscle mass by directly inhibiting LKB1 and stimulating STAT3 activities, respectively. AMPK, a downstream target of LKB1, was recently identified as a key molecule controlling autophagy. Here we identified that Fyn phosphorylates the α subunit of AMPK on Y436 and inhibits AMPK enzymatic activity without altering the assembly state of the AM...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.18632/oncotarget.11916

Authors


Yamada, E. More by this author
Bastie, C. C. More by this author
More by this author
Department:
Oxford, MSD, Obstetrics & Gynaecology
Nakajima, Y. More by this author
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Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
7
Issue:
46
Pages:
74612-74629
Publication date:
2016-09-08
Acceptance date:
2016-09-05
DOI:
ISSN:
1949-2553
Pubs id:
pubs:646060
URN:
uri:acbce6ce-b241-4fb4-a8c3-14f0b7fdba28
UUID:
uuid:acbce6ce-b241-4fb4-a8c3-14f0b7fdba28
Local pid:
pubs:646060
Language:
English
Keywords:

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