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The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc.

Abstract:

The intervertebral disc is the largest avascular tissue in the body. Its metabolism is mainly anaerobic, and thus lactate is produced at a significant rate. As a result the lactate concentrations in the center of the disc may be 8-10 times as high as in the plasma. The pH in the disc center is thus acidic. Because low values of pH are known to affect proteoglycan synthesis in other cartilages, the authors measured the effect of lactate levels and pH on 35S-sulphate and 3H-proline incorporatio...

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Publication status:
Published

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Journal:
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Volume:
17
Issue:
9
Pages:
1079-1082
Publication date:
1992-09-01
DOI:
EISSN:
1528-1159
ISSN:
0362-2436
Language:
English
Keywords:
Pubs id:
pubs:433372
UUID:
uuid:acb29eda-da4e-4425-918c-ae19fea21ff8
Local pid:
pubs:433372
Source identifiers:
433372
Deposit date:
2013-11-16

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