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MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition

Abstract:
Background Abdominal fat mass is associated with metabolic risk whilst gluteal femoral fat is paradoxically protective. MicroRNAs are known to be necessary for adipose tissue formation and function but their role in regulating human fat distribution remains largely unexplored.

Methods An initial microarray screen of abdominal subcutaneous and gluteal adipose tissue, with validatory qPCR, identified microRNA-196a as being strongly differentially exp... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0002-2422-248X
More from this funder
Name:
Oxford Biomedical Research Centre
Grant:
A93300
More from this funder
Name:
British Heart Foundation
Grant:
RG/17/1/32663
More from this funder
Name:
Wellcome Trust
Grant:
090532/Z/09/Z
Publisher:
Elsevier
Journal:
EBioMedicine More from this journal
Volume:
44
Pages:
467-475
Publication date:
2019-05-28
Acceptance date:
2019-05-21
DOI:
EISSN:
2352-3964
Pmid:
31151930
Language:
English
Keywords:
Pubs id:
pubs:1007255
UUID:
uuid:acab24f2-d92b-4825-a1b5-b6659b1348f1
Local pid:
pubs:1007255
Source identifiers:
1007255
Deposit date:
2019-06-19

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