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Journal article

Magnetic resonance imaging of pathological processes in rodent models of amyotrophic lateral sclerosis.

Abstract:

Non-human models of neurodegenerative diseases have potential for the identification of key pathways in pathogenesis and for the more rapid assessment of therapeutic candidates. While there are legitimate concerns about the physiological differences between the rodent and human motor systems, mice expressing the 'G93A' superoxide dismutase-1 gene mutation are a predictable and robustly-characterized model for amyotrophic lateral sclerosis (ALS). This model has provided evidence for an importa...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Volume:
13
Issue:
3
Pages:
288-301
Publication date:
2012-05-01
DOI:
EISSN:
1471-180X
ISSN:
1748-2968
Source identifiers:
245051
Language:
English
Keywords:
Pubs id:
pubs:245051
UUID:
uuid:aca86943-f8e5-42ee-9a9d-94bc24431970
Local pid:
pubs:245051
Deposit date:
2012-12-19

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