Journal article
A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.
- Abstract:
-
Mutations of the APC gene cause familial adenomatous polyposis (FAP) in humans and multiple intestinal neoplasia (Min) in laboratory mouse strains. A dominant modifying gene (Mom1), which partially suppresses the min phenotype, has been mapped to mouse chromosome 4. This region is syntenic with human chromosome 1p35-p36. The phospholipase A2 (Pla2s) locus is an excellent candidate for Mom1 and the equivalent human locus PLA2G2A is found on chromosome 1p35. It does not necessarily follow, howe...
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- Publisher copy:
- 10.1136/jmg.33.4.268
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Authors
Bibliographic Details
- Journal:
- Journal of medical genetics
- Volume:
- 33
- Issue:
- 4
- Pages:
- 268-273
- Publication date:
- 1996-04-05
- DOI:
- EISSN:
-
1468-6244
- ISSN:
-
0022-2593
- URN:
-
uuid:aca6a5ce-7379-4252-aba8-a624217664a6
- Source identifiers:
-
72305
- Local pid:
- pubs:72305
Item Description
Terms of use
- Copyright date:
- 1996
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