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A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.

Abstract:

Mutations of the APC gene cause familial adenomatous polyposis (FAP) in humans and multiple intestinal neoplasia (Min) in laboratory mouse strains. A dominant modifying gene (Mom1), which partially suppresses the min phenotype, has been mapped to mouse chromosome 4. This region is syntenic with human chromosome 1p35-p36. The phospholipase A2 (Pla2s) locus is an excellent candidate for Mom1 and the equivalent human locus PLA2G2A is found on chromosome 1p35. It does not necessarily follow, howe...

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Publisher copy:
10.1136/jmg.33.4.268

Authors


Tomlinson, IP More by this author
Talbot, IC More by this author
Spigelman, AD More by this author
Williams, CB More by this author
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Journal:
Journal of medical genetics
Volume:
33
Issue:
4
Pages:
268-273
Publication date:
1996-04-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:aca6a5ce-7379-4252-aba8-a624217664a6
Source identifiers:
72305
Local pid:
pubs:72305

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