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T-cell responses to the DBLα-tag, a short semi-conserved region of the Plasmodium falciparum membrane erythrocyte protein 1.

Abstract:

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant surface antigen expressed on mature forms of infected erythrocytes. It is considered an important target of naturally acquired immunity. Despite its extreme sequence heterogeneity, variants of PfEMP1 can be stratified into distinct groups. Group A PfEMP1 have been independently associated with low host immunity and severe disease in several studies and are now of potential interest as vaccine candidates. Although a...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0030095

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Journal:
PloS one More from this journal
Volume:
7
Issue:
1
Pages:
e30095
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203

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