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RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy.

Abstract:

We report here that joint inflammation in collagen-induced arthritis is more aggravated in CD44-knockout mice than in WT mice, and we provide evidence for molecular redundancy as a causal factor. Furthermore, we show that under the inflammatory cascade, RHAMM (receptor for hyaluronan-mediated motility), a hyaluronan receptor distinct from CD44, compensates for the loss of CD44 in binding hyaluronic acid, supporting cell migration, up-regulating genes involved with inflammation (as assessed by...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0407378102

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
52
Pages:
18081-18086
Publication date:
2004-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:ac8a668e-1a02-4de5-b679-b6e4cba28e0c
Source identifiers:
227318
Local pid:
pubs:227318

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