- Abstract:
-
We report here that joint inflammation in collagen-induced arthritis is more aggravated in CD44-knockout mice than in WT mice, and we provide evidence for molecular redundancy as a causal factor. Furthermore, we show that under the inflammatory cascade, RHAMM (receptor for hyaluronan-mediated motility), a hyaluronan receptor distinct from CD44, compensates for the loss of CD44 in binding hyaluronic acid, supporting cell migration, up-regulating genes involved with inflammation (as assessed by...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0407378102
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 101
- Issue:
- 52
- Pages:
- 18081-18086
- Publication date:
- 2004-12-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:ac8a668e-1a02-4de5-b679-b6e4cba28e0c
- Source identifiers:
-
227318
- Local pid:
- pubs:227318
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy.
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