- Abstract:
-
The ATP-sensitive K+ channel (KATP channel) couples glucose metabolism to insulin secretion in pancreatic beta-cells. It is comprised of sulfonylurea receptor (SUR)-1 and Kir6.2 proteins. Binding of Mg nucleotides to the nucleotide-binding domains (NBDs) of SUR1 stimulates channel opening and leads to membrane hyperpolarization and inhibition of insulin secretion. To elucidate the structural basis of this regulation, we constructed a molecular model of the NBDs of SUR1, based on the crystal s...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.2337/diabetes.53.suppl_3.S123
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- Volume:
- 53 Suppl 3
- Issue:
- SUPPL. 3
- Pages:
- S123-S127
- Publication date:
- 2004-12-05
- DOI:
- EISSN:
-
1939-327X
- ISSN:
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0012-1797
- URN:
-
uuid:ac8559f9-963f-4dfd-b15e-b047df641172
- Source identifiers:
-
100627
- Local pid:
- pubs:100627
- Keywords:
- Copyright date:
- 2004
Conference
Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.
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