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Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.

Abstract:

The ATP-sensitive K+ channel (KATP channel) couples glucose metabolism to insulin secretion in pancreatic beta-cells. It is comprised of sulfonylurea receptor (SUR)-1 and Kir6.2 proteins. Binding of Mg nucleotides to the nucleotide-binding domains (NBDs) of SUR1 stimulates channel opening and leads to membrane hyperpolarization and inhibition of insulin secretion. To elucidate the structural basis of this regulation, we constructed a molecular model of the NBDs of SUR1, based on the crystal s...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Volume:
53 Suppl 3
Issue:
SUPPL. 3
Pages:
S123-S127
Host title:
Diabetes
Publication date:
2004-12-01
Event location:
United States
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
100627

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