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Thesis

Neural vulnerability in models of Parkinson's disease

Abstract:

Parkinson's disease (PD) is a neurodegenerative disorder with no known cure. This thesis explores the degenerative process in two neurotoxin-based models, the 6-hydroxydopamine and the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)/probenecid mouse models, to yield important information about the pathogenesis of PD.

Neuronal survival patterns in Parkinsonian patients and animals are heterogeneous. More dopaminergic neurons are lost from the ventral tier of the substanti...

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Institution:
University of Oxford
Division:
MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2007
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
603851418
Language:
English
Subjects:
UUID:
uuid:ac82e1c1-5d9f-473f-97ac-fcb70b2587ca
Local pid:
td:603851418
Deposit date:
2014-04-01

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