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Journal article

Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion

Abstract:

The ligand for the c-Kit receptor, KitL, exists as a membrane-associated (mKitL) and a soluble form (sKitL). KitL functions outside c-Kit activation have not been identified. We show that co-culture of c-Kit- and mKitL-expressing NIH3T3 cells results in signaling through mKitL: c-Kit-bound mKitL recruits calcium-modulating cyclophilin ligand (CAML) to selectively activate Akt, leading to CREB phosphorylation, mTOR pathway activation, and increased cell proliferation. Activation of mKitL in th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-07024-0

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-9715-5951
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-0544-735X
More from this funder
Funding agency for:
Fischer, R
Medical Research Council More from this funder
National Institute for Health Research More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 4685
Publication date:
2018-11-08
Acceptance date:
2018-10-10
DOI:
EISSN:
2041-1723
Pubs id:
pubs:941313
URN:
uri:ac772267-9866-46fb-ac9b-0794e9061683
UUID:
uuid:ac772267-9866-46fb-ac9b-0794e9061683
Local pid:
pubs:941313
Language:
English
Keywords:

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