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Journal article

Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions

Abstract:

Kinetochores are dynamic cellular structures that connect chromosomes to microtubules. They form from multi-protein assemblies that are evolutionarily conserved between yeasts and humans. One of these assemblies-COMA-consists of subunits Ame1 CENP-U , Ctf19 CENP-P , Mcm21 CENP-O and Okp1 CENP-Q . A description of COMA molecular organization has so far been missing. We defined the subunit topology of COMA, bound with inner kinetochore proteins Nkp1 and Nkp2, from the yeast Kluyveromyces lactis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embj.201796636

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
Exeter College
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Robinson, C
Grant:
WT008150, WT099141
Publisher:
EMBO Press
Journal:
EMBO Journal More from this journal
Volume:
36
Issue:
23
Pages:
3458-3482
Publication date:
2017-10-18
Acceptance date:
2017-09-08
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Keywords:
Pubs id:
pubs:738761
UUID:
uuid:ac74ef35-4db1-4388-9d48-40db945228cd
Local pid:
pubs:738761
Source identifiers:
738761
Deposit date:
2017-10-27

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