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Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.

Abstract:

Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy characterized by a highly variable course and outcome. The disease is believed to be driven by B-cell receptor (BCR) signals generated by external antigens and/or cell-autonomous BCR interactions, but direct in vivo evidence for this is still lacking. To further define the role of the BCR pathway in the development and progression of CLL, we evaluated the capacity of different types of antigen/BCR interactions to induce leukemia...

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Authors


Iacovelli, S More by this author
Bennardo, S More by this author
Duehren-von Minden, M More by this author
Gobessi, S More by this author
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Journal:
Blood
Volume:
125
Issue:
10
Pages:
1578-1588
Publication date:
2015-03-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:ac6f0f15-2133-4ef8-9749-03a78f6582a8
Source identifiers:
503453
Local pid:
pubs:503453
Language:
English

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