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Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered.

Abstract:

CTLA-4 is a critical negative regulator of T cell responses and CTLA-4-deficient (CTLA-4(-/-)) mice die of a lymphproliferative disease. Nevertheless, RAG-2-deficient mice reconstituted with a mixture of CTLA-4(-/-) and normal (CTLA-4(+/+)) bone marrow survive in the absence of any signs of disease, although 50% of their T cells do not express CTLA-4. Using such mixed chimeras, we analyzed the role of CTLA-4 in specific T cell responses to lymphocytic choriomeningitis virus, Leishmania major ...

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Publication status:
Published

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Authors


Bachmann, MF More by this author
Gallimore, A More by this author
Ecabert, B More by this author
Acha-Orbea, H More by this author
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Journal:
European journal of immunology
Volume:
31
Issue:
2
Pages:
450-458
Publication date:
2001-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:ac6eec3f-9fa8-4ded-8511-e58d55e7a206
Source identifiers:
469159
Local pid:
pubs:469159

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