- Abstract:
-
Gelatinase B (MMP-9) and galectin-3 are widely known to participate in tumor cell invasion and metastasis. Glycans derived from MMP-9 expressed in MCF-7 breast cancer and THP-1 myeloid leukemia cells were compared with those from MMP-9 expressed in natural neutrophils. The many O-linked glycans of neutrophil gelatinase B presented a cluster of mainly galactosylated core II structures, 46% of which were ligands for galectin-3; 11% contained two to three N-acetyllactosamine repeating units that...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/bi0612541
-
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- Journal:
- BIOCHEMISTRY
- Volume:
- 45
- Issue:
- 51
- Pages:
- 15249-15258
- Publication date:
- 2006-12-26
- DOI:
- ISSN:
-
0006-2960
- URN:
-
uuid:ac6d9951-56de-4654-bdf7-0b90f24e3e1b
- Source identifiers:
-
100493
- Local pid:
- pubs:100493
- Language:
- English
- Copyright date:
- 2006
Journal article
Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3
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