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Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3

Abstract:

Gelatinase B (MMP-9) and galectin-3 are widely known to participate in tumor cell invasion and metastasis. Glycans derived from MMP-9 expressed in MCF-7 breast cancer and THP-1 myeloid leukemia cells were compared with those from MMP-9 expressed in natural neutrophils. The many O-linked glycans of neutrophil gelatinase B presented a cluster of mainly galactosylated core II structures, 46% of which were ligands for galectin-3; 11% contained two to three N-acetyllactosamine repeating units that...

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Publication status:
Published

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Publisher copy:
10.1021/bi0612541

Authors


Van den Steen, PE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Leathem, AJ More by this author
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Journal:
BIOCHEMISTRY
Volume:
45
Issue:
51
Pages:
15249-15258
Publication date:
2006-12-26
DOI:
ISSN:
0006-2960
URN:
uuid:ac6d9951-56de-4654-bdf7-0b90f24e3e1b
Source identifiers:
100493
Local pid:
pubs:100493
Language:
English

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