Journal article

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Abstract:: Background: Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine. Expression of these enzymes is frequently observed in advanced-stage cancers and is associated with poor disease prognosis and immune suppression. Mechanistically, the respective roles of tryptophan shortage and kynurenine production in suppressing immunity remain unclear. Kynurenine was proposed as an endogenous li...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Solvay, M., Holfelder, P., Klaessens, S., Pilotte, L., Stroobant, V., Lamy, J., Naulaerts, S., Spillier, Q., Frédérick, R., De Plaen, E., Sers, C., Opitz, C. A., Van den Eynde, B. J., & Zhu, J. (2023). Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes. Journal for Immunotherapy of Cancer, 11(6).

MLA Style

Solvay, M., et al. “Tryptophan Depletion Sensitizes the AHR Pathway by Increasing AHR Expression and GCN2/LAT1-Mediated Kynurenine Uptake, and Potentiates Induction of Regulatory T Lymphocytes.” Journal for Immunotherapy of Cancer, vol. 11, no. 6, BMJ Publishing Group, 2023.

Chicago Style

Solvay, M, P Holfelder, S Klaessens, L Pilotte, V Stroobant, J Lamy, S Naulaerts, et al. 2023. “Tryptophan Depletion Sensitizes the AHR Pathway by Increasing AHR Expression and GCN2/LAT1-Mediated Kynurenine Uptake, and Potentiates Induction of Regulatory T Lymphocytes.” Journal for Immunotherapy of Cancer 11 (6).
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Files:: Solvay_et_al_2023_tryptophan_depletion_sensitizes.pdf

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Publisher copy:: 10.1136/jitc-2023-006728

Authors

+ Solvay, M More by this author

Role:

Author

+ Holfelder, P More by this author

Role:

Author

ORCID:

0000-0002-0945-678X

+ Klaessens, S More by this author

Role:

Author

+ Pilotte, L More by this author

Role:

Author

ORCID:

0000-0001-6761-6836

+ Stroobant, V More by this author

Role:

Author

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Funding

+ Le Fonds de la Recherche Fondamentale Stratégique More from this funder

Grant:

WELBIO-CR-2019C-05

Bibliographic Details

Publisher:: BMJ Publishing Group
Journal:: Journal for Immunotherapy of Cancer More from this journal
Volume:: 11
Issue:: 6
Article number:: e006728
Place of publication:: England
Publication date:: 2023-06-21
Acceptance date:: 2023-05-12
DOI:: 10.1136/jitc-2023-006728
EISSN:: 2051-1426
ISSN:: 2051-1426
Pmid:: 37344101

Item Description

Language:: English
Keywords:: receptors

T-Lymphocytes

FFR

tryptophan

regulatory

aryl hydrocarbon

HEK293 Cells

kynurenine

mice
Pubs id:: 1489461
Local pid:: pubs:1489461
Deposit date:: 2023-07-19

Terms of use

Copyright holder:: Solvay et al
Copyright date:: 2023
Rights statement:: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Licence:: CC Attribution-NonCommercial (CC BY-NC)

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