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Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation.

Abstract:

The hippocampus is an important mediator of learning and reinforcement, but its role in cocaine effects has received little attention. Neuronal activity in the hippocampus and the nucleus accumbens (Nac) depend on serotonergic (5-HT) transmission. Here we describe for the first time a cocaine-induced increase in 5-HT concentration in the hippocampus and the Nac parallel to behavioral activation. In addition, pretreatment with the 5-HT(1A)-receptor antagonist WAY 100635 blocked the behavioral ...

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Publisher copy:
10.1002/syn.10083

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Synapse (New York, N.Y.) More from this journal
Volume:
45
Issue:
2
Pages:
67-77
Publication date:
2002-08-01
DOI:
EISSN:
1098-2396
ISSN:
0887-4476
Language:
English
Keywords:
Pubs id:
pubs:241329
UUID:
uuid:ac55cb96-e656-40d5-9221-48f135df9317
Local pid:
pubs:241329
Source identifiers:
241329
Deposit date:
2013-11-16

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