- Abstract:
-
The helix-loop-helix (HLH) domain is employed by many transcription factors that control cell fate choice in multiple developmental settings. Previously, we demonstrated that the HLH domain of the class II basic HLH (bHLH) protein SCL/Tal-1 is critical for hematopoietic specification. We have now identified residues in this domain that are essential for restoring hematopoietic development to SCL-/- embryonic stem cells and sufficient to convert a muscle-specific HLH domain to one able to resc...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/mcb.24.17.7491-7502.2004
-
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- Journal:
- Molecular and cellular biology
- Volume:
- 24
- Issue:
- 17
- Pages:
- 7491-7502
- Publication date:
- 2004-09-05
- DOI:
- EISSN:
-
1098-5549
- ISSN:
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0270-7306
- URN:
-
uuid:ac5590f2-6eb8-44af-9601-3fdce930b333
- Source identifiers:
-
39117
- Local pid:
- pubs:39117
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
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