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Journal article

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.

Abstract:

The helix-loop-helix (HLH) domain is employed by many transcription factors that control cell fate choice in multiple developmental settings. Previously, we demonstrated that the HLH domain of the class II basic HLH (bHLH) protein SCL/Tal-1 is critical for hematopoietic specification. We have now identified residues in this domain that are essential for restoring hematopoietic development to SCL-/- embryonic stem cells and sufficient to convert a muscle-specific HLH domain to one able to resc...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Molecular and cellular biology
Volume:
24
Issue:
17
Pages:
7491-7502
Publication date:
2004-09-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:ac5590f2-6eb8-44af-9601-3fdce930b333
Source identifiers:
39117
Local pid:
pubs:39117

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