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Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model.

Abstract:

OBJECTIVE: To identify novel microRNA (miR) associations in synovial fibroblasts (SF), by performing miR expression profiling on cells isolated from the human tumour necrosis factor (TNF) transgenic mouse model (TghuTNF, Tg197) and patients biopsies. METHODS: miR expression in SF from TghuTNF and wild-type (WT) control mice were determined by miR deep sequencing (miR-seq) and the arthritic profile was established by pairwise comparisons. Quantitative PCR analysis was utilised for profile vali...

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Publication status:
Published

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Volume:
71
Issue:
10
Pages:
1716-1723
Host title:
Annals of the rheumatic diseases
Publication date:
2012-10-01
Event location:
England
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Source identifiers:
221715

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