- Abstract:
-
PURPOSE: The majority of breast cancer patients who have estrogen receptor positive (ER(+)) tumors whose proliferation is reduced after estrogen deprivation by aromatase inhibitors (AI). This study investigates any link between proliferation and hypoxia, a major determinant of tumor biology, and defines the effect of estrogen deprivation on hypoxia-associated genes. METHODS: Genome-wide expression profiles were obtained from tumor biopsies from 81 ER(+) postmenopausal patients, before and aft...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1158/1078-0432.ccr-10-1704
-
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- Journal:
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Volume:
- 17
- Issue:
- 9
- Pages:
- 3005-3012
- Publication date:
- 2011-05-05
- DOI:
- EISSN:
-
1557-3265
- ISSN:
-
1078-0432
- URN:
-
uuid:ac4e9fa8-a6b0-4902-b187-99a10d996398
- Source identifiers:
-
303710
- Local pid:
- pubs:303710
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer.
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