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Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer.

Abstract:

PURPOSE: The majority of breast cancer patients who have estrogen receptor positive (ER(+)) tumors whose proliferation is reduced after estrogen deprivation by aromatase inhibitors (AI). This study investigates any link between proliferation and hypoxia, a major determinant of tumor biology, and defines the effect of estrogen deprivation on hypoxia-associated genes. METHODS: Genome-wide expression profiles were obtained from tumor biopsies from 81 ER(+) postmenopausal patients, before and aft...

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Publication status:
Published

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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
17
Issue:
9
Pages:
3005-3012
Publication date:
2011-05-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:ac4e9fa8-a6b0-4902-b187-99a10d996398
Source identifiers:
303710
Local pid:
pubs:303710

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