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Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases.

Abstract:

The causes of most neurological disorders are not fully understood. Inflammation and blood-brain barrier dysfunction appear to play major roles in the pathology of these diseases. Inflammatory insults that occur during brain development may have widespread effects later in life for a spectrum of neurological disorders. In this review, a new hypothesis suggesting a mechanistic link between inflammation and blood-brain barrier function (integrity), which is universally important in both neurode...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Neuropathology and applied neurobiology
Volume:
35
Issue:
2
Pages:
132-146
Publication date:
2009-04-01
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
Source identifiers:
271265
Language:
English
Keywords:
Pubs id:
pubs:271265
UUID:
uuid:ac4dd29a-ded9-42e4-ba84-963fa8f4b920
Local pid:
pubs:271265
Deposit date:
2012-12-19

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