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The role of photon scattering in voltage-calcium fluorescent recordings of ventricular fibrillation

Abstract:

Recent optical mapping studies of cardiac tissue suggest that membrane voltage (V m) and intracellular calcium concentrations (Ca) become dissociated during ventricular fibrillation (VF), generating a proarrhythmic substrate. However, experimental methods used in these studies may accentuate measured dissociation due to differences in fluorescent emission wavelengths of optical voltage/calcium (V opt/Ca opt) signals. Here, we simulate dual voltage-calcium optical mapping experiments using a m...

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Publisher copy:
10.1016/j.bpj.2011.06.012

Authors


Journal:
Biophysical Journal More from this journal
Volume:
101
Issue:
2
Pages:
307-318
Publication date:
2011-07-20
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Language:
English
Pubs id:
pubs:179750
UUID:
uuid:ac4940ce-f7ea-42bb-93ac-c020eda33f6e
Local pid:
pubs:179750
Source identifiers:
179750
Deposit date:
2012-12-19

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