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Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis.

Abstract:

BACKGROUND: We aimed to determine the antibody and T cell responses to Burkholderia pseudomallei of humans to select candidate vaccine antigens. METHODS: For antibody profiling, a protein microarray of 154 B. pseudomallei proteins was probed with plasma from 108 healthy individuals and 72 recovered patients. Blood from 20 of the healthy and 30 of the recovered individuals was also obtained for T cell assays. RESULTS: Twenty-seven proteins distinctively reacted with human plasma following env...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jiq142

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Journal of infectious diseases
Volume:
203
Issue:
7
Pages:
1002-1011
Publication date:
2011-04-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
133563
Language:
English
Keywords:
Pubs id:
pubs:133563
UUID:
uuid:ac46cad0-9a08-4f85-9f1f-84dde4c1207d
Local pid:
pubs:133563
Deposit date:
2014-07-16

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