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Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets

Abstract:

Non-typhoidal Salmonella (NTS) are highly prevalent food-borne pathogens. Recently, a highly invasive, multi-drug resistant S. Typhimurium, ST313, emerged as a major cause of bacteraemia in children and immunosuppressed adults, however the pathogenic mechanisms remain unclear. Here, we utilize invasive and non-invasive Salmonella strains combined with single-cell RNA-sequencing to study the transcriptome of individual infected and bystander monocyte-derived dendritic cells (MoDCs) implicated ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-07329-0

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Green Templeton College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
KIR
Department:
Oxford,MSD,NDORMS, KIR
Role:
Author
ORCID:
0000-0003-3899-3872
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
CCMP
Role:
Author
ORCID:
0000-0001-5120-3578
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Simmons, A
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Preciado-Llanes, L
Simmons, A
More from this funder
Name:
Medical Research Council
Funding agency for:
Aulicino, A
Preciado-Llanes, L
Napolitani, G
Simmons, A
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
9
Article number:
4883
Publication date:
2018-11-19
Acceptance date:
2018-10-25
DOI:
ISSN:
2041-1723
Pmid:
30451854
Language:
English
Pubs id:
pubs:944474
UUID:
uuid:ac439813-9398-43ae-ac95-098fe4257957
Local pid:
pubs:944474
Source identifiers:
944474
Deposit date:
2018-11-28

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