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Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV-1 latency

Abstract:

Background While antiretroviral therapies have improved life expectancy and reduced viral loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral replication. This suggests that a reservoir of latently-infected cells remains within these patients, the identity of which is ill-defined and therefore difficult to target therapeutically. Current strategies are aimed at using drugs such as histone deacetylase (HDAC) inhibitors to induce the expression of late...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12977-016-0242-4

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
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Funding agency for:
Frater, J
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Funding agency for:
Magiorkinis, G
Publisher:
BioMed Central Publisher's website
Journal:
Retrovirology Journal website
Publication date:
2016-02-06
DOI:
ISSN:
1742-4690
URN:
uuid:ac4136df-4aca-48e1-b09c-46d427394a3a
Source identifiers:
599385
Local pid:
pubs:599385

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