Journal article
Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV-1 latency
- Abstract:
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Background While antiretroviral therapies have improved life expectancy and reduced viral loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral replication. This suggests that a reservoir of latently-infected cells remains within these patients, the identity of which is ill-defined and therefore difficult to target therapeutically. Current strategies are aimed at using drugs such as histone deacetylase (HDAC) inhibitors to induce the expression of late...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 1.3MB)
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- Publisher copy:
- 10.1186/s12977-016-0242-4
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Authors
Funding
+ Oxford NIHR Comprehensive Biomedical Research Centre
More from this funder
Funding agency for:
Frater, J
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Retrovirology Journal website
- Publication date:
- 2016-02-06
- DOI:
- ISSN:
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1742-4690
- URN:
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uuid:ac4136df-4aca-48e1-b09c-46d427394a3a
- Source identifiers:
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599385
- Local pid:
- pubs:599385
Terms of use
- Copyright holder:
- Hurst et al.
- Copyright date:
- 2016
- Notes:
- © 2016 Hurst et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. This is the publisher's version of the article. The final version is available online from BioMed Central at: [10.1186/s12977-016-0242-4]
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