- Abstract:
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Background While antiretroviral therapies have improved life expectancy and reduced viral loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral replication. This suggests that a reservoir of latently-infected cells remains within these patients, the identity of which is ill-defined and therefore difficult to target therapeutically. Current strategies are aimed at using drugs such as histone deacetylase (HDAC) inhibitors to induce the expression of late...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 1.3mb)
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- Publisher copy:
- 10.1186/s12977-016-0242-4
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- Funding agency for:
- Frater, J
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Retrovirology Journal website
- Publication date:
- 2016-02-06
- DOI:
- ISSN:
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1742-4690
- URN:
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uuid:ac4136df-4aca-48e1-b09c-46d427394a3a
- Source identifiers:
-
599385
- Local pid:
- pubs:599385
- Copyright holder:
- Hurst et al.
- Copyright date:
- 2016
- Notes:
- © 2016 Hurst et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. This is the publisher's version of the article. The final version is available online from BioMed Central at: [10.1186/s12977-016-0242-4]
Journal article
Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV-1 latency
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+ Oxford NIHR Comprehensive Biomedical Research Centre
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