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Choosing the target difference ('effect size') for a randomised controlled trial - DELTA(2) guidance protocol.

Abstract:

BACKGROUND: A key step in the design of a randomised controlled trial (RCT) is the estimation of the number of participants needed. By far the most common approach is to specify a target difference and then estimate the corresponding sample size; this sample size is chosen to provide reassurance that the tr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13063-017-1969-5

Authors


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Department:
St Hughs College
Julious, SA More by this author
More by this author
Department:
Oxford, MSD, NDORMS, CSM
Rothwell, JC More by this author
Ramsay, CR More by this author
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Medical Research Council/National Institute for Health Research More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
18
Issue:
271
Pages:
1-7
Publication date:
2017-06-12
Acceptance date:
2017-05-04
DOI:
EISSN:
1745-6215
Pubs id:
pubs:700948
URN:
uri:ac3b4c68-ec37-4fb5-9f6e-d0bdde78383d
UUID:
uuid:ac3b4c68-ec37-4fb5-9f6e-d0bdde78383d
Local pid:
pubs:700948

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