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Choosing the target difference ('effect size') for a randomised controlled trial - DELTA(2) guidance protocol.

Abstract:

BACKGROUND: A key step in the design of a randomised controlled trial (RCT) is the estimation of the number of participants needed. By far the most common approach is to specify a target difference and then estimate the corresponding sample size; this sample size is chosen to provide reassurance that the trial will have high statistical power to detect such a difference between the randomised groups (at the planned statistical significance level). The sample size has many implications for ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13063-017-1969-5

Authors


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Institution:
University of Oxford
Oxford college:
St Hugh's College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
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Medical Research Council/National Institute for Health Research More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
18
Issue:
271
Pages:
1-7
Publication date:
2017-06-12
Acceptance date:
2017-05-04
DOI:
EISSN:
1745-6215
Source identifiers:
700948
Language:
English
Keywords:
Pubs id:
pubs:700948
UUID:
uuid:ac3b4c68-ec37-4fb5-9f6e-d0bdde78383d
Local pid:
pubs:700948
Deposit date:
2017-07-03

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