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The DURATIONS randomised trial design: estimation targets, analysis methods and operating characteristics

Abstract:

Background: Designing trials to reduce treatment duration is important in several therapeutic areas, including tuberculosis and bacterial infections. We recently proposed a new randomised trial design to overcome some of the limitations of standard two-arm non-inferiority trials. This DURATIONS design involves randomising patients to a number of duration arms, and modelling the so-called ‘duration-response curve’. This article investigates the operating characteristics (ty...

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Publication status:
Accepted
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1740774520944377

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-0412-8509
Publisher:
SAGE Publications
Journal:
Clinical Trials More from this journal
Volume:
17
Issue:
6
Pages:
644-653
Publication date:
2020-08-16
Acceptance date:
2020-06-29
DOI:
EISSN:
1740-7753
ISSN:
1740-7745
Language:
English
Keywords:
Pubs id:
1116379
Local pid:
pubs:1116379
Deposit date:
2020-07-04

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