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Journal article

Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.

Abstract:

OBJECTIVES: The heritability of RA has been estimated to be approximately 55%, of which the MHC contributes about one-third. HLA-DRB1 alleles are strongly associated with RA, but it is likely that significant non-DRB1 MHC genetic susceptibility factors are involved. Previously, we identified two three-marker haplotypes in a 106-kb region in the MHC class III region immediately centromeric to TNF, which are strongly associated with RA on HLA-DRB1*0404 haplotypes. In the present study, we aime...

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Publication status:
Published

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Publisher copy:
10.1093/rheumatology/ken376

Authors


Harney, SM More by this author
Vilariño-Güell, C More by this author
Adamopoulos, IE More by this author
Lawrence, RW More by this author
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Journal:
Rheumatology (Oxford, England)
Volume:
47
Issue:
12
Pages:
1761-1767
Publication date:
2008-12-05
DOI:
EISSN:
1462-0332
ISSN:
1462-0324
URN:
uuid:ac3016ce-3589-43e5-b3fd-0cdb542a6029
Source identifiers:
107887
Local pid:
pubs:107887

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