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Human genetics as a model for target validation: finding new therapies for diabetes

Abstract:

Type 2 diabetes is a global epidemic with major effects on healthcare expenditure and quality of life. Currently available treatments are inadequate for the prevention of comorbidities, yet progress towards new therapies remains slow. A major barrier is the insufficiency of traditional preclinical models for predicting drug efficacy and safety. Human genetics offers a complementary model to assess causal mechanisms for target validation. Genetic perturbations are ‘experiments of nature’ that ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Gloyn, A
Grant:
Senior Fellow in Basic Biomedical Science (095101/Z/10/Z and 200837/Z/16/Z)
More from this funder
Name:
Radcliffe Department of Medicine, University of Oxford
Funding agency for:
Thomsen, S
Publisher:
Springer Berlin Heidelberg
Journal:
Diabetologia More from this journal
Volume:
60
Issue:
6
Pages:
960-970
Publication date:
2017-04-26
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Keywords:
Pubs id:
pubs:697113
UUID:
uuid:ac2dbd81-4d5a-4061-bd02-263016f08ac0
Local pid:
pubs:697113
Deposit date:
2017-06-13

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