Journal article
From basic to clinical neuropharmacology: targetophilia or pharmacodynamics?
- Abstract:
-
Historically, much drug discovery and development in psychopharmacology tended to be empirical. However, over the last 20 years it has primarily been target oriented, with synthesis and selection of compounds designed to act at a specific neurochemical site. Such compounds are then examined in functional animal models of disease. There is little evidence that this approach (which we call 'targetophilia') has enhanced the discovery process and some indications that it may have retarded it. A m...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- British journal of clinical pharmacology
- Volume:
- 73
- Issue:
- 6
- Pages:
- 959-967
- Publication date:
- 2012-06-01
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:312944
- UUID:
-
uuid:ac2a8b13-af6e-474d-9140-d4c7fe970a4a
- Local pid:
- pubs:312944
- Source identifiers:
-
312944
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2012
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