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From basic to clinical neuropharmacology: targetophilia or pharmacodynamics?

Abstract:

Historically, much drug discovery and development in psychopharmacology tended to be empirical. However, over the last 20 years it has primarily been target oriented, with synthesis and selection of compounds designed to act at a specific neurochemical site. Such compounds are then examined in functional animal models of disease. There is little evidence that this approach (which we call 'targetophilia') has enhanced the discovery process and some indications that it may have retarded it. A m...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Role:
Author
Journal:
British journal of clinical pharmacology
Volume:
73
Issue:
6
Pages:
959-967
Publication date:
2012-06-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:ac2a8b13-af6e-474d-9140-d4c7fe970a4a
Source identifiers:
312944
Local pid:
pubs:312944

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