Journal article icon

Journal article

2-(2-haloalkenyl)-aryl halides as substrates for palladium-catalysed tandem C-N bond formation: Efficient synthesis of 1-substituted indoles

Abstract:

2-(2-Haloalkenyl)-aryl halides, conveniently prepared in a single step from the corresponding o-halobenzaldehydes, are combined with amines under Pd catalysis to provide 1-substituted indoles. All combinations of Br and Cl leaving groups can be employed, and a range of substituents on the arene, alkene and amine, can all be tolerated. The use of 1,3-dichloro-substituted arenes allows a third amination process to take place; these three-component processes deliver the corresponding 4-aminoindo...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/adsc.200505484

Authors


Willis, MC More by this author
Findlay, TJK More by this author
Holmes, IP More by this author
Journal:
ADVANCED SYNTHESIS and CATALYSIS
Volume:
348
Issue:
7-8
Pages:
851-856
Publication date:
2006-05-05
DOI:
EISSN:
1521-3897
ISSN:
1615-4150
URN:
uuid:ac2a7d20-c009-4d04-85f5-88757855b670
Source identifiers:
52509
Local pid:
pubs:52509

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP