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The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.

Abstract:

Case-control studies suggest that the CTLA-4 gene may be a susceptibility locus for Graves' disease. The previously reported A/G polymorphism at position 49 in exon 1 of the CTLA-4 gene was, therefore, investigated in a case-control (n = 743) and family-based (n = 179) dataset of white Caucasian subjects with Graves' disease. The relationship between CTLA-4 genotype and severity of thyroid dysfunction at diagnosis was also investigated. An increase in frequency of the G (alanine) allele was s...

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Publisher copy:
10.1210/jc.84.7.2398

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
84
Issue:
7
Pages:
2398-2401
Publication date:
1999-07-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:ac29c949-5b74-4595-b050-7b0238ad31f5
Source identifiers:
176302
Local pid:
pubs:176302

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