- Abstract:
-
Case-control studies suggest that the CTLA-4 gene may be a susceptibility locus for Graves' disease. The previously reported A/G polymorphism at position 49 in exon 1 of the CTLA-4 gene was, therefore, investigated in a case-control (n = 743) and family-based (n = 179) dataset of white Caucasian subjects with Graves' disease. The relationship between CTLA-4 genotype and severity of thyroid dysfunction at diagnosis was also investigated. An increase in frequency of the G (alanine) allele was s...
Expand abstract - Publisher copy:
- 10.1210/jc.84.7.2398
-
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- Journal:
- The Journal of clinical endocrinology and metabolism
- Volume:
- 84
- Issue:
- 7
- Pages:
- 2398-2401
- Publication date:
- 1999-07-05
- DOI:
- EISSN:
-
1945-7197
- ISSN:
-
0021-972X
- URN:
-
uuid:ac29c949-5b74-4595-b050-7b0238ad31f5
- Source identifiers:
-
176302
- Local pid:
- pubs:176302
- Copyright date:
- 1999
Journal article
The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.
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