- Abstract:
-
Lysis of human lymphocytes by autologous complement had been studied using a range of monoclonal antibodies against different antigens. Antigen specificity (and not antibody isotype) was the most important factor which influenced cell lysis and this could not be accounted for merely by differences in surface density between antigens. Three antigens with comparable surface density were studied in detail: CAMPATH-1 (lytic), major histocompatibility complex class I (lytic) and leukocyte common a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/eji.1830181006
-
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- Journal:
- European journal of immunology
- Volume:
- 18
- Issue:
- 10
- Pages:
- 1507-1514
- Publication date:
- 1988-10-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:ac244151-d478-4336-89ed-678bab1eda87
- Source identifiers:
-
20327
- Local pid:
- pubs:20327
- Language:
- English
- Keywords:
- Copyright date:
- 1988
Journal article
Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.
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