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Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.

Abstract:

Lysis of human lymphocytes by autologous complement had been studied using a range of monoclonal antibodies against different antigens. Antigen specificity (and not antibody isotype) was the most important factor which influenced cell lysis and this could not be accounted for merely by differences in surface density between antigens. Three antigens with comparable surface density were studied in detail: CAMPATH-1 (lytic), major histocompatibility complex class I (lytic) and leukocyte common a...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830181006

Authors


Bindon, CI More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
European journal of immunology
Volume:
18
Issue:
10
Pages:
1507-1514
Publication date:
1988-10-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:ac244151-d478-4336-89ed-678bab1eda87
Source identifiers:
20327
Local pid:
pubs:20327

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