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CPT1a-dependent long-chain fatty acid oxidation contributes to maintaining glucagon secretion from pancreatic islets

Abstract:

Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show that glucagon secretion in low glucose conditions is maintained by fatty acid metabolism in both mouse and human islets, and that inhibiting this metabolic pathway profoundly decre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.05.035

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Rorsman, NJG More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
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Funding agency for:
Briant, LJB
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Funding agency for:
Briant, LJB
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Funding agency for:
Knudsen, JG
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
11
Pages:
3300-3311
Publication date:
2018-06-13
Acceptance date:
2018-05-02
DOI:
ISSN:
2211-1247
Pubs id:
pubs:846583
URN:
uri:ac1eecb1-818f-4151-89f6-5b8573296e00
UUID:
uuid:ac1eecb1-818f-4151-89f6-5b8573296e00
Local pid:
pubs:846583

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