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Journal article

CPT1a-dependent long-chain fatty acid oxidation contributes to maintaining glucagon secretion from pancreatic islets

Abstract:

Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show that glucagon secretion in low glucose conditions is maintained by fatty acid metabolism in both mouse and human islets, and that inhibiting this metabolic pathway profoundly decre...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.05.035

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
More from this funder
Name:
Novo Nordisk
Funding agency for:
Knudsen, JG
Grant:
Postdoctoral fellowship
More from this funder
Name:
Trinity College, Oxford
Funding agency for:
Briant, LJB
Grant:
Junior Research Fellowship
More from this funder
Name:
Wellcome Trust
Funding agency for:
Briant, LJB
Grant:
Junior Research Fellowship
095531/Z/11/Z
More from this funder
Name:
European Research Council
Grant:
322620
More from this funder
Name:
Goodger and Schorstein Scholarship
Grant:
2015
Publisher:
Cell Press
Journal:
Cell Reports More from this journal
Volume:
23
Issue:
11
Pages:
3300-3311
Publication date:
2018-06-13
Acceptance date:
2018-05-02
DOI:
ISSN:
2211-1247
Keywords:
Pubs id:
pubs:846583
UUID:
uuid:ac1eecb1-818f-4151-89f6-5b8573296e00
Local pid:
pubs:846583
Deposit date:
2018-05-08

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