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Anomeric specificity of D-xylose isomerase.

Abstract:

Crystal structures of complexes of D-xylose isomerase with deoxysugars have been determined. Deoxynojirimycin is a structural analogue of alpha-pyranose and mimics the binding of these aldose substrates. The structure of this complex supports the hypothesis that an imidazole group catalyzes ring opening of the pyranose. The steric restrictions in the active site of the enzyme prevent a beta-pyranose from binding in the same way. For the reverse reaction with ketoses, the anomeric specificity ...

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Publication status:
Published

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Publisher copy:
10.1021/bi00163a034

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Journal:
Biochemistry
Volume:
31
Issue:
48
Pages:
12211-12218
Publication date:
1992-12-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:ac1c0175-df48-461b-b8e0-0fc65aacf6f1
Source identifiers:
44077
Local pid:
pubs:44077

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