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T Cells infiltrating diseased liver express ligands for the NKG2D stress surveillance system.

Abstract:

NK cells, which are highly enriched in the liver, are potent regulators of antiviral T cells and immunopathology in persistent viral infection. We investigated the role of the NKG2D axis in T cell/NK cell interactions in hepatitis B. Activated and hepatitis B virus (HBV)-specific T cells, particularly the CD4 fraction, expressed NKG2D ligands (NKG2DL), which were not found on T cells from healthy controls (p < 0.001). NKG2DL-expressing T cells were strikingly enriched within HBV-infected l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.4049/jimmunol.1601313

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ORCID:
0000-0002-9736-9933
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ORCID:
0000-0001-6413-919X
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ORCID:
0000-0001-6064-8624
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
198
Issue:
3
Pages:
1172-1182
Publication date:
2017-01-05
Acceptance date:
2016-11-22
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:816574
URN:
uri:ac199be6-e3e7-479b-857e-59320659b483
UUID:
uuid:ac199be6-e3e7-479b-857e-59320659b483
Local pid:
pubs:816574

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