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Behavioural characterisation of the robotic mouse mutant.

Abstract:

The ataxic mouse mutant robotic is characterised by progressive adult-onset Purkinje cell loss that occurs in a distinctive region-specific pattern. We report the first behavioural characterisation of this mutant and quantify its performance on tests of motor function, locomotor and exploratory activity over a time course that reflects specific stages of cell loss in the cerebellum. Robotic mutants are significantly impaired on the rotarod and static rod tests of coordination and their perfor...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbr.2007.04.012

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Behavioural brain research
Volume:
181
Issue:
2
Pages:
239-247
Publication date:
2007-08-05
DOI:
EISSN:
1872-7549
ISSN:
0166-4328
URN:
uuid:ac16a844-85f9-47bb-9228-6d6ffdd5f537
Source identifiers:
106525
Local pid:
pubs:106525

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