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Evolutionary analysis reveals low coverage as the major challenge for protein interaction network alignment.

Abstract:

Local alignments of protein interaction networks have found little conservation among several species. While this could be a consequence of the incompleteness of interaction data-sets and presence of error, an intriguing prospect is that the process of network evolution is sufficient to erase any evidence of conservation. Here, we aim to test this hypothesis using models of network evolution and also investigate the role of error in the results of network alignment. We devised a distance metr...

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Publication status:
Published

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Publisher copy:
10.1039/c004430j
Journal:
Molecular bioSystems More from this journal
Volume:
6
Issue:
11
Pages:
2296-2304
Publication date:
2010-11-01
DOI:
EISSN:
1742-2051
ISSN:
1742-206X
Language:
English
Keywords:
Pubs id:
pubs:110915
UUID:
uuid:ac11f00f-9f1a-46e4-a94d-537df372c7cc
Local pid:
pubs:110915
Source identifiers:
110915
Deposit date:
2012-12-19

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