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Journal article

Evolutionary analysis reveals low coverage as the major challenge for protein interaction network alignment.

Abstract:

Local alignments of protein interaction networks have found little conservation among several species. While this could be a consequence of the incompleteness of interaction data-sets and presence of error, an intriguing prospect is that the process of network evolution is sufficient to erase any evidence of conservation. Here, we aim to test this hypothesis using models of network evolution and also investigate the role of error in the results of network alignment. We devised a distance metr...

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Publication status:
Published

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Publisher copy:
10.1039/c004430j

Authors


Journal:
Molecular bioSystems
Volume:
6
Issue:
11
Pages:
2296-2304
Publication date:
2010-11-05
DOI:
EISSN:
1742-2051
ISSN:
1742-206X
URN:
uuid:ac11f00f-9f1a-46e4-a94d-537df372c7cc
Source identifiers:
110915
Local pid:
pubs:110915

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