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Cak1 is required for Kin28 phosphorylation and activation in vivo.

Abstract:

Complete activation of most cyclin-dependent protein kinases (CDKs) requires phosphorylation by the CDK-activating kinase (CAK). In the budding yeast, Saccharomyces cerevisiae, the major CAK is a 44-kDa protein kinase known as Cak1. Cak1 is required for the phosphorylation and activation of Cdc28, a major CDK involved in cell cycle control. We addressed the possibility that Cak1 is also required for the activation of other yeast CDKs, such as Kin28, Pho85, and Srb10. We generated three new te...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
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Journal:
Molecular and cellular biology
Volume:
18
Issue:
11
Pages:
6365-6373
Publication date:
1998-11-01
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
36238

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