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Journal article

Single-molecule detection of coumarin-120

Abstract:
Two-photon excitation with a mode-locked titanium: sapphire laser at 700 nm and confocal fluorescence microscopy have been used to detect single Coumarin-120 (C-120) molecules. The dye C-120 is quenched by the nucleobases, if coupled to nucleotides, resuiting in nucleobase-specific fluorescence lifetimes. This suggests applications in current projects for ultrasensitive DNA characterization.
Publication status:
Published

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Publisher copy:
10.1080/07328319708002915

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
NUCLEOSIDES and NUCLEOTIDES More from this journal
Volume:
16
Issue:
5-6
Pages:
551-556
Publication date:
1997-01-01
DOI:
ISSN:
0732-8311
Pubs id:
pubs:222219
UUID:
uuid:ac0cc1fc-fcce-4fd6-a624-7b60406c14b9
Local pid:
pubs:222219
Source identifiers:
222219
Deposit date:
2012-12-19

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