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Biosensor architectures for high-fidelity reporting of cellular signaling.

Abstract:

Understanding mechanisms of information processing in cellular signaling networks requires quantitative measurements of protein activities in living cells. Biosensors are molecular probes that have been developed to directly track the activity of specific signaling proteins and their use is revolutionizing our understanding of signal transduction. The use of biosensors relies on the assumption that their activity is linearly proportional to the activity of the signaling protein they have been...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2014.06.021

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Biophysical Society
Journal:
Biophysical journal
Volume:
107
Issue:
3
Pages:
773-782
Publication date:
2014-08-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
478842
Language:
English
Pubs id:
pubs:478842
UUID:
uuid:ac0b2db1-fcad-4284-a774-1c1d61cbcdb2
Local pid:
pubs:478842
Deposit date:
2014-08-23

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