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Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.

Abstract:

In RA (and in collagen-induced arthritis in DBA/l mice) experimental evidence has convincingly demonstrated the therapeutic benefit of anti-TNF-α antibodies, whereas anti-TNF-α also induces lupus-associated DNA antibodies in a minority of presumably genetically susceptible individuals, and accelerates SLE nephritis in NZB/W mice whose disease is suppressed by anti-IL-10. Conversely, TNF-α replacement protects NZB/W F1 mice from developing SLE, as does anti-IL-10 therapy, by inducing TNF-α. Li...

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Publication status:
Published

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Publisher copy:
10.1007/bf00197526

Authors


Elliott, MJ More by this author
Charles, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Publisher:
Springer-Verlag
Journal:
Springer seminars in immunopathology
Volume:
16
Issue:
2-3
Pages:
327-336
Publication date:
1994
DOI:
EISSN:
1432-2196
ISSN:
0344-4325
URN:
uuid:ac053ca9-fe98-47d9-97d5-e9d7c6fe1af5
Source identifiers:
481667
Local pid:
pubs:481667

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