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A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.

Abstract:

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain and#8764;25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002333

Authors


Surakka, I More by this author
Karssen, LC More by this author
Laurila, PP More by this author
Middelberg, RP More by this author
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European Community's Seventh Framework Programme More from this funder
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Grant:
HEALTH-F4-2007-201413
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
10
Pages:
e1002333
Publication date:
2011-10-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:ac030d24-25ec-47e3-a3d7-cd5f12a80660
Source identifiers:
206248
Local pid:
pubs:206248

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