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Assembly of human small nuclear RNA gene-specific transcription factor IIIB complex de novo on and off promoter.

Abstract:

In humans, transcription factor IIIB (TFIIIB)-alpha governs basal transcription from small nuclear RNA genes by RNA polymerase III (pol III). One of the components of this complex, BRFU/TFIIIB50, is specific for these promoters, whereas TATA-binding protein (TBP) and hB" are required for pol III transcription from both gene external and internal promoters. We show that hB" is specifically recruited to a promoter-bound TBP.BRFU complex, which we have previously demonstrated as forming on TATA-...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m203119200

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The Journal of biological chemistry
Volume:
277
Issue:
30
Pages:
26831-26838
Publication date:
2002-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ac02c28e-8838-4c1b-83b2-3e3ba130a213
Source identifiers:
12364
Local pid:
pubs:12364

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