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Red light, green light: probing single molecules using alternating-laser excitation.

Abstract:

Single-molecule fluorescence methods, particularly single-molecule FRET (fluorescence resonance energy transfer), have provided novel insights into the structure, interactions and dynamics of biological systems. ALEX (alternating-laser excitation) spectroscopy is a new method that extends single-molecule FRET by providing simultaneous information about structure and stoichiometry; this new information allows the detection of interactions in the absence of FRET and extends the dynamic range of...

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Publication status:
Published

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Publisher copy:
10.1042/bst0360738

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
Journal:
Biochemical Society transactions
Volume:
36
Issue:
Pt 4
Pages:
738-744
Publication date:
2008-08-01
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Source identifiers:
20533
Language:
English
Keywords:
Pubs id:
pubs:20533
UUID:
uuid:abfdba97-e301-4657-9fdc-966ebf8c318a
Local pid:
pubs:20533
Deposit date:
2012-12-19

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