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Automated solid-phase extraction method for the determination of atovaquone in plasma and whole blood by rapid high-performance liquid chromatography.

Abstract:

A bioanalytical method for the determination of atovaquone in plasma and whole blood by solid-phase extraction and high-performance liquid chromatography has been developed and validated. A structurally similar internal standard was added and protein was precipitated from plasma and whole blood with acetonitrile before being loaded on to a C8 solid-phase extraction column. Atovaquone and internal standard were analysed by high-performance liquid chromatography on a C18 J'Sphere ODS-M80 (150x4...

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Publication status:
Published

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Authors


Lindegårdh, N More by this author
Bergqvist, Y More by this author
Journal:
Journal of chromatography. B, Biomedical sciences and applications
Volume:
744
Issue:
1
Pages:
9-17
Publication date:
2000-07-05
DOI:
ISSN:
1387-2273
URN:
uuid:abfbac14-8198-447b-805c-8ed685d19a44
Source identifiers:
12010
Local pid:
pubs:12010

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