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Lipid bilayer composition influences the activity of the antimicrobial peptide dermcidin channel

Abstract:

Antimicrobial peptides (AMPs) carry great potential as new antibiotics against “superbugs.” Dermcidin (DCD), a broad-spectrum AMP in human sweat, has been recently crystallized in its oligomeric state and showed channel-like properties. In this work, we performed multiscale molecular dynamics simulations to study how the membrane composition influences the behavior of a transmembrane pore formed by the DCD oligomer in the hope of revealing the origin of the membrane selectivity of this AMP to...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2019.03.033

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Christ Church
Role:
Author
ORCID:
0000-0001-6360-7959
More from this funder
Name:
Wellcome Trust
Grant:
208361/Z/17/Z
More from this funder
Name:
Leverhulme Trust
Grant:
RPG-2013-393
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Name:
European Commission
Grant:
327051
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Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/L002558/1
Publisher:
Elsevier
Journal:
Biophysical Journal More from this journal
Volume:
116
Issue:
9
Pages:
1658-1666
Publication date:
2019-04-05
Acceptance date:
2019-03-28
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Language:
English
Keywords:
Pubs id:
pubs:987737
UUID:
uuid:abf5440d-dc7d-4737-b684-1a42abf95ef2
Local pid:
pubs:987737
Source identifiers:
987737
Deposit date:
2019-04-09

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